Yet, no effects are observed in other large trials ( 20, 23– 25). In a small trial of Japanese patients with early type 2 diabetes, intensive insulin treatment was associated with improvement in selected DSPN measures ( 22), and the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial reported a modest but significant DSPN risk reduction with the glycemia intervention in individuals with type 2 diabetes after 5 years of follow-up ( 21). In contrast, enhanced glucose control in people with type 2 diabetes reduces the risk of developing DSPN modestly (5%–9% relative risk reduction) ( 20, 21). Nondiabetic neuropathies common in diabetesĬhronic inflammatory demyelinating polyneuropathyĪcute painful small-fiber neuropathies (treatment-induced)Įnhanced glucose control in people with type 1 diabetes dramatically reduces the incidence of DSPN (78% relative risk reduction) ( 17– 19). lumbosacral polyradiculopathy, proximal motor amyotrophy) Radiculopathy or polyradiculopathy (atypical forms) Mononeuritis multiplex (if confluent may resemble polyneuropathy)Ĭ. Isolated cranial or peripheral nerve (e.g., CN III, ulnar, median, femoral, peroneal) Mononeuropathy (mononeuritis multiplex) (atypical forms) Diabetic cystopathy (neurogenic bladder)ī.Mixed small- and large-fiber neuropathy (most common).
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